With the continuous progress of biotechnology, fermentation systems are increasingly widely used in the biopharmaceutical industry. The purpose of this paper is to discuss the new trend of fermentation system design, and combined with the actual needs of the biopharmaceutical industry, put forward a series of practical measures, in order to provide reference for the design and optimization of fermentation systems in the industry.

The biopharmaceutical industry is a strategic emerging industry that our country focuses on the development of, and the advantages and disadvantages of the system design of the fermentation technology, as the core process of the biopharmaceutical, are directly related to the production efficiency, product quality, and product quality. The advantages and disadvantages of its system design are directly related to the production efficiency, cost control and market competitiveness of the products. With the rapid development of bioengineering technology, fermentation system design also presents new trends. This paper will analyze these new trends and discuss how to apply them in practice.

1.New Trends in Fermentation System Design

Intelligentization and Automation

With the development of technologies such as artificial intelligence, big data, and Internet of Things (IoT), the design of fermentation system is moving in the intelligentization and automation direction. Intelligent fermentation systems can monitor and adjust key parameters in the fermentation process in real time, realizing precise control of the fermentation process.

Microbial diversity

The diversity of biopharmaceutical products requires that the fermentation system design be able to adapt to the growth needs of different microorganisms. As a result, fermentation system design tends to support the fermentation of a wider variety of microorganisms, including extremophiles and difficult-to-cultivate microorganisms.

Environmental protection and sustainability

Environmental protection and sustainability are hot issues of global concern, and fermentation system design is also striving to reduce energy consumption and waste emissions, and to realize green production.

System integration and modularization

In order to improve productivity and flexibility, fermentation system design tends to be integrated and modularized, which makes the fermentation process more flexible and easy to regulate.

2. Practical measures for fermentation system design

Construction of an intelligent fermentation system

(1) Introducing advanced sensors: installing sensors of temperature, pH, dissolved oxygen, turbidity, and so on, and real-time monitoring of the fermentation process.

(2) Data collection and analysis: collect fermentation data by using big data technology and optimize the fermentation process through data analysis.

(3) Intelligent control system: based on machine learning algorithms, realize automatic control and optimization of fermentation process.

Design to adapt to microbial diversity

(1) Multi-functional fermenter: design fermenters that can adapt to the needs of different microorganisms, e.g., adjustable pH, temperature, and dissolved oxygen.

(2) Customized media: develop customized media according to the nutritional needs of different microorganisms.

Environmental protection and sustainability realization

(1) Energy-saving design: adopt energy-efficient mixing system, heat exchanging equipment, etc. to reduce energy consumption.

(2) Waste treatment: design the waste treatment system to realize the resource utilization of fermentation waste.

System integration and modularization implementation

(1) Standardized components: develop standardized components such as fermenters, pipelines, control systems, etc., for quick assembly and replacement.

(2) Modularized design: Divide the fermentation system into multiple modules, and flexibly combine them according to production needs.

New trends in the design of fermentation systems present unprecedented opportunities for the biopharmaceutical industry. Through practical measures of intelligence, adaptation to microbial diversity, environmental protection and sustainability, as well as system integration and modularization, the performance of fermentation systems can be effectively enhanced to meet the development needs of the biopharmaceutical industry. In the future, fermentation system design will continue to innovate and provide strong support for the continued development of the biopharmaceutical industry.