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Application and sustainability of fermentation system technology in the biopharmaceutical industry
2024-10-16

Fermentation system technology is one of the key technologies in the biopharmaceutical industry, which is of great significance in promoting the sustainable development of the industry. This paper discusses three aspects of the application status quo, sustainable development strategy and future development trend of fermentation system technology in the biopharmaceutical industry, aiming to provide reference for the green development of the biopharmaceutical industry.



The biopharmaceutical industry is a strategic emerging industry in China, and fermentation system technology, as its core support technology, plays an important role in improving drug production, reducing production cost and realizing green production. This paper will analyze the application and sustainable development path of fermentation system technology in the biopharmaceutical industry.

Application of fermentation system technology in biopharmaceutical industry

1. Antibiotic production

Fermentation system technology has a wide range of applications in antibiotic production such as penicillin, cephalosporin, and so on. By optimizing the fermentation process, the yield and purity of antibiotics are improved.

2. Biological vaccine preparation

Fermentation system technology is used for the production of viral vaccines, bacterial vaccines, etc., such as influenza vaccine and hepatitis B vaccine. Advances in fermentation technology have provided for the large-scale production of vaccines.

3. Production of biologically active substances

Fermentation system technology can be used for the production of a wide range of biologically active substances, such as enzymes, hormones, polysaccharides, etc., which have a wide range of applications in the fields of pharmaceuticals, food, and agriculture.

4. Biosimilar development

Fermentation system technology is an important tool for biosimilar development, which can be used to produce highly active and pure biopharmaceuticals through fermentation, and to reduce the production cost.

Sustainable development strategy of fermentation system technology

1. Strain resource protection and development

Strengthening the collection, preservation, and evaluation of strain resources, and rationally developing new strains to avoid excessive strain resource development and degradation.

2. Optimization of fermentation process

Through the optimization of fermentation process, the utilization rate of raw materials can be improved, the energy consumption and waste emission can be reduced, and clean production can be realized.

3. Resourceful utilization of waste

Resourceful treatment of waste generated in the fermentation production process, such as wastewater treatment, exhaust gas purification, etc., to reduce environmental pollution.

4. Efficient utilization of energy

Adopt energy-saving fermentation equipments to improve the efficiency of energy utilization and reduce the production cost.

Future development trend of fermentation system technology

1. Intelligent fermentation process

Use IoT, big data, artificial intelligence and other technologies to realize real-time monitoring and intelligent control and improve production efficiency.

2. Microbiome engineering

Through microbiome engineering, we can construct highly efficient and stable fermentation flora to improve the yield of target products.

3. Environmentally friendly fermentation processes

Developing new environmentally friendly fermentation processes, such as solid-state fermentation, liquid fermentation, etc., to reduce the impact on the environment.

4. Interdisciplinary research and innovation

Strengthening cross research with other disciplines, such as bioinformatics, materials science, etc., to promote the innovation and development of the technology of fermentation system.


Fermentation system technology in the biopharmaceutical industry has a broad application prospect, and the realization of its sustainable development is of great significance in promoting the green development of the whole industry. China should continue to increase research and development efforts to promote the development of fermentation system technology in the direction of high efficiency, environmental protection and intelligence, and contribute to the sustainable development of the biopharmaceutical industry.


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