Fermentation technology is one of the most important tools in the biopharmaceutical industry, through the cultivation, propagation and metabolism of microorganisms to achieve the production of target products. This paper focuses on "Operation of Fermentation Systems", discussing the application of fermentation system operation in the biopharmaceutical industry and the development of key technologies.

Biopharmaceuticals It is a method of producing drugs using living organisms (including microorganisms, plant and animal cells, etc.). Fermentation technology, as the core link of biopharmaceuticals, has the advantages of high production efficiency, lower cost and environmental protection. In recent years, with the continuous development of biotechnology, fermentation system operation has been more and more widely used in the biopharmaceutical industry. In this paper, we will discuss the key technologies and applications of fermentation system operation in the biopharmaceutical industry from the perspective of its operation.

Overview of Fermentation System Operation

1. Composition of Fermentation System

The fermentation system is mainly composed of the following parts: fermenter, control system, gas supply system, cooling system, defoaming system, sampling system and so on.

2. Basic principles of fermentation process

The fermentation process is a process in which microorganisms utilize the substrate for growth, reproduction and metabolism under suitable conditions. By adjusting the fermentation conditions, the regulation of microbial growth and metabolism can be realized, thus increasing the yield of the target product.

Fermentation system operations in the biopharmaceutical industry

1. Antibiotic production

Antibiotics are one of the important products in the biopharmaceutical industry, and the fermentation system operation plays an important role in antibiotic production. By optimizing the fermentation conditions, the antibiotic yield can be increased and the production cost can be reduced.

2. Bio-vaccine production

Bio-vaccines are an important means of preventing infectious diseases, and the fermentation system operation plays a key role in bio-vaccine production. For example, influenza vaccine and hepatitis B vaccine need to be produced by fermentation system.

3. Production of biologically active substances

Fermentation system operations can also be used to produce a variety of biologically active substances, such as enzymes, hormones, growth factors and so on. These substances have a wide range of applications in the fields of medicine, agriculture, and food.

4. Brewing industry

Fermentation system operation is also of great importance in the brewing industry. By controlling the fermentation conditions, the alcohol yield can be increased and the quality of the wine can be improved.

Key technologies for fermentation system operation

1. Selection and breeding of fermentation strains

Selection and breeding of high-yielding and stable fermentation strains is the key to improve fermentation yield. Strains with excellent fermentation performance can be obtained through mutagenesis, screening and optimization.

2. Optimization of fermentation process

The optimization of fermentation process includes the adjustment of the fermentation conditions, medium formulation, and gas supply method. By optimizing the fermentation process, the yield of the target product and the fermentation efficiency can be improved.

3. Fermentation process control

Fermentation process control is the key to ensure the stable operation of the fermentation system. It mainly includes real-time monitoring and regulation of temperature, pH, dissolved oxygen, rotational speed and other parameters.

4. Improvement of fermentation equipment

Improvement of fermentation equipment can help to improve the productivity of fermentation system. For example, the use of new fermenters and automatic control systems can reduce energy consumption and increase production.

Fermentation system operation is increasingly widely used in the biopharmaceutical industry, and the research and improvement of key technologies are of great significance to improve fermentation yield and reduce production costs. With the continuous development of biotechnology, fermentation system operation will play a greater role in the biopharmaceutical industry. China should increase the research and industrialization of fermentation technology to provide strong support for the sustainable development of the biopharmaceutical industry.