Fermentation system technology is an important bioengineering technology, which is widely used in the field of biopharmaceuticals. This paper mainly introduces the current application status and development trend of fermentation system technology in the biopharmaceutical industry as well as the research progress in this field in China, aiming to provide useful reference for the biopharmaceutical industry.
Biopharmaceuticals It is a method of producing drugs by biotechnological means using living organisms or their components. Fermentation system technology, as one of the core technologies of biopharmaceuticals, has the advantages of high production efficiency, lower cost and environmental protection. In recent years, with the continuous development of biotechnology, the application of fermentation system technology in the biopharmaceutical industry is becoming more and more widespread, which brings great development opportunities for China's biopharmaceutical industry.
1. Antibiotic production
Antibiotic is an important product in the field of biopharmaceuticals, and the fermentation system technology has a pivotal position in antibiotic production. Through the fermentation system, antibiotics such as penicillin, cephalosporin, erythromycin and so on can be produced efficiently to meet the clinical needs.
2. Bio-vaccine production
Vaccine is an effective means of preventing infectious diseases, and the technology of fermentation system plays an important role in bio-vaccine production. For example, influenza vaccine and hepatitis B vaccine are produced using fermentation systems.
3. Production of biologically active substances
Fermentation system technology can be used for the production of a variety of biologically active substances, such as enzymes, hormones, growth factors and so on. These bioactive substances have a wide range of applications in the fields of medicine, agriculture, and food.
4. Brewing industry
Fermentation system technology has a long history of application in the brewing industry, which mainly includes the production of liquor, beer and wine. Through the fermentation system, the sugar in the raw material can be converted into alcohol to realize the brewing process.
5. Food additives production
Fermentation system technology can be used to produce a wide range of food additives, such as citric acid, lactic acid, acetic acid and so on. These food additives play an important role in improving the taste of food and extending shelf life.
1. Application of genetic engineering technology in fermentation system
The development of genetic engineering technology has brought new opportunities for fermentation system technology. By means of gene editing and regulation, the yield and stability of fermentation strains can be improved and efficient production can be realized.
2. Intelligence of fermentation process control technology
With the development of automation and informatization technology, the fermentation process control technology has gradually realized intelligence. Through real-time monitoring of key parameters in the fermentation process, precise control of the fermentation process can be realized and product quality can be improved.
3. Green environment protection of fermentation system
Environmental protection is a growing concern, and fermentation system technology needs to pay attention to green environment protection in the development process. Such as the use of non-polluting, renewable raw materials, optimize the fermentation process, reduce energy consumption and so on.
Four, China's fermentation system technology in the biopharmaceutical industry research progress
In recent years, China has achieved a series of research results in the field of fermentation system technology, as follows:
1 . Selection, breeding and construction of high-yielding strains
Through genetic engineering technology, Chinese researchers have successfully selected and constructed a number of high-yielding strains, such as high-yielding penicillin strains, high-yielding erythromycin strains, and so on.
2. Optimization and control of fermentation process
Chinese researchers have achieved remarkable results in optimization and control of fermentation process, such as fermentation tank design, optimization of fermentation process, and so on.
3. Research and application of novel fermentation systems
Chinese researchers have made breakthroughs in the research of novel fermentation systems, such as the membrane fermentation technology and the solid-state fermentation technology.
In short, the application of fermentation system technology in the biopharmaceutical industry has a broad prospect. China should continue to increase research efforts to promote the innovative development of fermentation system technology in the field of biopharmaceuticals, and contribute to China's biopharmaceutical industry.