In the biopharmaceutical industry, the monitoring of glucose and lactate concentrations during cell culture is important for understanding the cell growth status and regulating metabolic pathways. However, traditional detection methods often have problems such as complex operation and poor real-time performance, which seriously affect the efficiency of cell culture. For this reason, our research team has developed an on-line glucose/lactate sensor based on the electrochemical principle of enzyme, CITSens Bio, which brings a new solution to the biopharmaceutical industry.

Introduction of CITSens Bio Sensor System

1. Principle of operation

The CITSens Bio Sensor System utilizes the principle of enzyme electrochemistry, in which current signals are generated through the reaction of a specific enzyme with glucose and lactate molecules. The sensor converts the current signals into concentration information, enabling real-time monitoring of glucose and lactate during cell culture.

2. Applications

The CITSens Bio sensor systems are suitable for in media for cell culture as well as in matrices with complex compositions. In the biopharmaceutical industry, applications are available for continuous on-line/on-site measurements of cell lines, culture media and during process development programs.

3. Product Advantages

(1) Real-Time: CITSens Bio Sensor The system data generation frequency is 20 seconds/time, which can reflect the changes of glucose and lactate concentration during cell culture in real time.

(2) Wireless communication: The sensor system can communicate wirelessly through the closed incubator, which is convenient for users to keep track of the cell culture status.

(3) Ease of use: Users can observe the cell culture status throughout the day through smartphones and other devices for remote monitoring.

(4) Integration: The CITSens Bio sensor system can be directly connected to the OPC server to realize online inspection of process control technology.

CITSens Bio in the biopharmaceutical industry

1. Cell growth status monitoring

By monitoring glucose and lactate concentrations in real time, the CITSens Bio sensor system displays growth behaviors and metabolic status relevant to cell culture. This helps researchers better understand cell growth patterns and optimize culture conditions.

2. Process control technology

CITSens The Bio Sensor System detects glucose consumption and lactate production in real time to provide data support for process control techniques. Optimization of the cell culture process is achieved by adjusting the medium composition, temperature and other parameters.

3. Process Development and Optimization

In the process development project, the CITSens Bio sensor system can help researchers keep track of glucose and lactic acid concentration changes in real time, providing a basis for process optimization. This improves product quality and reduces production costs.

CITSens Bio on-line glucose/lactic acid sensor system has wide application prospects in the bio-pharmaceutical industry due to the advantages of real-time, wireless communication, ease-of-use and integration. It has a wide range of application prospects. It is believed that CITSens Bio will bring more innovations and breakthroughs to China's biopharmaceutical industry with the continuous advancement of technology.